Dermal Skin Substitutes for Upper Limb Reconstruction

Upper limb flaps for hand reconstruction.

This article reviews three of the most popular upper limb flaps used in hand surgery, namely the posterior interosseous flap, the lateral arm flap and the radial forearm flap. An anatomic study performed with the use of eight fresh cadavers (sixteen upper limbs) is supported by a wide review of the literature. The combined posterior interosseous and lateral arm flap is also discussed. It is con...

Update on dermal substitutes.

Tissue-engineered biological dressings offer promise in the treatment of burns, chronic ulcers, donor site and other surgical wounds, and a variety of dermatologic conditions. Despite this promise, cellular tissue-engineered products such a Dermagraft and Apligraf have suffered setbacks in recent years with a lower market share than the commercial promoters of these products anticipated. AlloDe...

cell therapy for dermal reconstruction

Dermal Substitutes Use in Reconstructive Surgery for Skin Tumors: A Single-Center Experience

Reconstructive surgery following skin tumor resection can be challenging. Treatment options after removing the tumor are skin grafting, local pedicled and axial flaps, or microsurgery for complex and extensive wounds correction. Recently, the use of dermal substitutes has been extended to reconstructive surgery in cutaneous oncology. Objectives. To report both a single-center experience using d...

Dermal Substitutes Support the Growth of Human Skin-Derived Mesenchymal Stromal Cells: Potential Tool for Skin Regeneration

New strategies for skin regeneration are needed in order to provide effective treatment for cutaneous wounds and disease. Mesenchymal stem cells (MSCs) are an attractive source of cells for tissue engineering because of their prolonged self-renewal capacity, multipotentiality, and ability to release active molecules important for tissue repair. In this paper, we show that human skin-derived mes...